منابع مشابه
5. DNA polymerase eta
DNA polymerase (Pol ) is the only one of the fifteen human DNA-dependent DNA polymerases for which a natural occurring deficiency is known to predispose humans to cancer. Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder, associated with a greatly increased risk of sunlightinduced skin tumors, and individuals with the variant type of this syndrome, XP-V, have defects in Pol ...
متن کاملMismatch extension ability of yeast and human DNA polymerase eta.
DNA polymerase eta (Poleta) functions in error-free replication of UV-damaged DNA, and in vitro it efficiently bypasses a cis-syn T-T dimer by incorporating two adenines opposite the lesion. Steady state kinetic studies have shown that both yeast and human Poleta are low-fidelity enzymes, and they misincorporate nucleotides with a frequency of 10(-2)-10(-3) on both undamaged and T-T dimer-conta...
متن کاملMutation frequencies and spectra in DNA polymerase eta-deficient mice.
The low-fidelity polymerase eta (poleta) is required for bypass of UV-induced pyrimidine dimers inserting adenine nucleotides opposite these lesions. Mutations in the poleta gene are responsible for the genetic defect in xeroderma pigmentosum variant patients. To study if the lack of poleta significantly elevates spontaneous mutation frequency in various organs and tissues of the mouse, we cros...
متن کاملRegulation of translesion synthesis DNA polymerase eta by monoubiquitination.
DNA polymerase eta is a Y family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous interaction between the PIP box in pol eta and PCNA and between the UBZ in pol eta and monoubiquitin attached to PCNA. Whereas monoubiquitination of PCNA is required for its interaction with pol eta during TLS, we now show that monoubiquitination of pol eta inhibits this ...
متن کاملError-prone lesion bypass by human DNA polymerase eta.
DNA lesion bypass is an important cellular response to genomic damage during replication. Human DNA polymerase eta (Pol(eta)), encoded by the Xeroderma pigmentosum variant (XPV) gene, is known for its activity of error-free translesion synthesis opposite a TT cis-syn cyclobutane dimer. Using purified human Pol(eta), we have examined bypass activities of this polymerase opposite several other DN...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37726